Petformance NoDolPet Every day: a revolutionary product containing curcumin – MERIVA® (Indena, Milan) – to help maintain normal bone and joint functions.
Petformance NoDolPet Every day has been specifically developed for treating chronic inflammatory conditions in pets, often suffering from arthritic and degenerative articular diseases as they age. Due to its specific formula, Petformance NoDolPet Every day exclusive in the veterinary field, is particularly suitable in these cases:
- in long-term treatments as support for normal
• in animals subjected to high joint stress;
• in elderly animals;
• as adjuvant during post-traumatic articular treatments;
• in the multimodal management of dogs with osteoarthritis, dysplasia and
post-traumatic articular diseases.
NoDolPet Every day is designed as a long-term maintenance treatment for chronic inflammatory conditions.
Thanks to the specific formulation made from curcumin phytosome (Meriva®), Petformance NoDolPet Every day
• ensures greater bioavailability of curcumin;
• supports the normal function of the joints;
• helps the normal function of the osteo-articular system;
• helps protect cells from oxidative stress;
• helps maintain the normal function of the gastrointestinal system.
PETFORMANCE NoDolPet Every day (tablets) is complementary feed particularly suited for keeping your dog or cat in perfect physical shape and for supporting physiological osteo-articular function.
Western science only recently acknowledged the properties of curcumin, a compound derived from Turmeric (Curcuma Longa L.) with anti-inflammatory and antioxidant properties. From the point of view of absorption, curcumin has low bioavailability and poor stability in biological systems. Thanks to the presence of an innovative patented complex of turmeric extract and phospholipids– MERIVA® (Indena, Milano) – Petformance NoDolPet Every day overcomes these issues, showing a marked improvement in absorption and, therefore, of the effectiveness of the active ingredient.
Petformance NoDolPet Every day has been specifically developed for treating chronic inflammatory conditions in pets, often suffering from arthritic and degenerative articular diseases as they age.
Due to its specific formula, Petformance NoDolPet Every day exclusive in the veterinary field, is particularly suitable in these cases:
- in long-term treatments as support for normal joint functions
• in animals subjected to high joint stress
• in elderly animals
• as adjuvant during post-traumatic articular treatments
• in the multimodal management of dogs with osteoarthritis, dysplasia and post-traumatic articular diseases.
Fermadol Every day is designed as a long-term maintenance treatment for chronic inflammatory inflammatory conditions.
NoDolPet Forte is recommended as an integration during acute phases and NoDolPet Every day during chronic ones. NoDolPet can be used to integrate therapies with traditional anti-inflammatory drugs in acute phases.
High palatability. Easy administration.
According to clinical trials, the Curcumin contained in Petformance NoDolPet demonstrates its potential to help maintain the normal function of the osteo-articular system often affected by inflammatory processes. A recent European study analysed the activity of Curcumin phytosome in non-steroidal anti-inflammatory drugs and showed that their bioactivity is similar.
Several studies have also demonstrated the hepato-protective effects of curcumin, leading researchers to suggest that its use can help protect the liver from exogenous insults and environmental toxins.
Curcumin, contained in Performance NoDolPet, plays a role in the normal function of the body’s antioxidant systems, helping protect cells from oxidative stress.
In a number of studies, Curcumin showed the ability to maintain a healthy bowel lining in various adverse conditions. It has also emerged that in subjects with poor gastrointestinal health, the administration of curcumin helps improve overall well-being.
Curcumin, administered with the absorption technology – Fitosoma –represents a step forward because:
- Marks a rise in bioavailability;
• Significantly increases clinical benefits;
• Ensures delivery to target cell tissues.
- Main features: Tablets with an innovative formula
to keep the animal in perfect physical shape.
Anti-inflammatory and pain-relieving.
• Intended for: Dogs and Cats.
• Administration: 900mg tablets.
Toy-sized dogs (under 10 kg of live weight): ¼ tablet a day;
Small dogs (between 10 kg and 20 kg of live weight): ½ tablet a day;
Medium dogs (between 20 kg and 40 kg of live weight): 1 tablet a day;
Large dogs (between 40 kg and 60 kg of live weight): 1 and ½ tablet a day.
Very large dogs (over 60 kg of live weight): 2 tablets a day.
Administration (cats): ½ tablet a day.
• Directions for use: add the tablets to normal
• Packaging: Blister pack of 30 x 900mg tablets.
What are phytosomes? Phytosomes are the result of a patented process that associates a botanical extract with a phospholipid – in this case soy lecithin, which has a high affinity with cell membranes. Unlike other plant extracts, this unique compound called Fitosoma easily crosses the intestinal barrier, which results in significantly higher levels of the active ingredient in the blood. Therefore, Petformance Fermadol provides a bioavailability of curcumine’s active ingredient in higher amounts compared to than any Curcuma longa extract currently available.
What is MERIVA®?
MERIVA® is a form of administration of curcumin(1) with a registered trademark (Indena, Milan). Curcumin and soy lecithin are formulated in a 1:2 ratio, obtaining a standardised total curcuminoid content of 18-22%. The obtained complex is called FITOSOMA®.
The Phytosomic technology
MERIVA® is the result of Indena phytosomal technology, a patented technology that significantly increases the bioavailability of compounds normally characterised by low solubility in biological matrices. (2,3) Curcumin has low solubility in water, chemical instability at the intestinal pH value, reduced oral bioavailability and a rapid metabolisation, which means that achieving effective concentrations is subject to limitations. As it is a poorly water-soluble phenolic compound, curcumin is able to form non-covalent bonds with phospholipids, especially phosphatidylcholine (FITOSOMA®).
The formation of such a complex is capable of improving the pharmacokinetic characteristics of curcumin, protecting the molecule from hydrolysis and operating a stabilising action with intestinal pH values. Moreover, by making the most of the rapid exchange of phosphatidylcholine between biological membranes and interstitial fluids, the phytosomic complex is able to act as a carrier for curcumin itself within the cell membranes (4), allowing for the transition from the luminous side to the visceral side of the enterocytes, resulting in a substantial increase in curcumin absorption.
Curcumin: a mechanism of action and rationale
Natural curcumin is obtained by extraction from the rhizome of turmeric (Curcuma Longa L.). Natural curcumin is mixed with a small amount of its mono and bis-demethoxylated derivatives, bis-demethoxycycur and demethoxycycurine. The composition of MERIVA® reflects natural curcuma. Recent studies indicate that the mixture of curcumin and demethoxycycurine is more stable than curcumin alone, suggesting a stabilising action of demethoxycycurine (5).
In vitro and in vivo studies in animal models have shown that curcumin acts as a general switch of the inflammation by operating at an enzymatic level (cyclooxygenase and lipoxygenase, COXs and LOs), at a transcriptional level (NF-kB) and at a genomic level on cellular factors involved in inflammatory processes. (6) Its wide range of biological activities and low oral toxicity make it potentially useful in many clinical conditions. The management of osteoarthritis is one of the best opportunities for the use of curcumin in Petformance NoDolPet, and relies on ethno-pharmacological documentation and an excellent mechanistic rationale. Indeed, it has been demonstrated that curcumin is able to protect chondrocytes from the catabolic action of inflammatory cytokines (IL-1beta, AP-1, NF-kB) and enzymes (MMP-3, collagenase) by blocking the degradation of proteoglycans(7) . The phytosomal curcumin present in Petformance NoDolPet can be used as a complementary treatment for the treatment of acute osteoarthritis in combination with anti-inflammatory drugs, allowing for better clinical results whilst providing a gastro-protective action. Curcumin is also a gastro-protective agent (8,9) that can protect against the side effects of many anti-inflammatory drugs through a down regulation of the expression of COX-2 at a gastric level. The lack of long-term side effects and the considerable safety of use (justified by a LD50 value>2g/kg in mice) means that Petformance NoDolPet is indicated as the only maintenance treatment during chronic phases, especially to reduce pain and increase the mobility of subjects.